Measles Aerosol Vaccine Project - Report to Sage
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چکیده
GOAL OF THE MEASLES AEROSOL VACCINE PROJECT .................................................................................. 1 WHY A MEASLES AEROSOL VACCINE? .......................................................................................................... 1 The potential to reduce the challenges link to injection safety and waste management ....................... 1 Positive lessons learned from polio campaigns suggest that a vaccine that can be given by volunteers and be provided house to house can reach high coverage in low resource environments ..................... 2 IS THE MEASLES AEROSOL VACCINE SAFE? .................................................................................................. 3 IS THE MEASLES AEROSOL VACCINE EFFICACIOUS AND EFFECTIVE? ........................................................... 4 Evidence on immunogenicity of Measles Aerosol Vaccine in infants below 10 months of age ............... 4 Evidence on immunogenicity of Measles Aerosol Vaccine in older infants and children ................. 5 Evidence on immunogenicity of measles aerosol vaccine when administered as a second dose. .......... 7 Evidence of long-term persistence of measles antibody titer after measles aerosol vaccine administration ........................................................................................................................................... 7 Evidence of impact of measles aerosol vaccine when used during outbreaks ......................................... 8 Evidence on the efficacy and effectiveness of measles injectable vaccine in infants and older children 8 Evidence on the cost and cost-effectiveness of a measles aerosol vaccine ................................................. 9 Assessment of the usability and acceptability of a measles aerosol vaccine ............................................. 10 Evidence on immunogenicity of Aerosol Measles Rubella and measles Rubella Mumps containing vaccines ....................................................................................................................................................... 11 Potential additional research ...................................................................................................................... 11 REFERENCES ................................................................................................................................................ 12
منابع مشابه
A randomized, controlled trial of an aerosolized vaccine against measles.
BACKGROUND Aerosolized vaccine can be used as a needle-free method of immunization against measles, a disease that remains a major cause of illness and death. Data on the immunogenicity of aerosolized vaccine against measles in children are inconsistent. METHODS We conducted an open-label noninferiority trial involving children 9.0 to 11.9 months of age in India who were eligible to receive a...
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The reactogenicity and immunogenicity of combined measles and rubella (MR) booster vaccination, via aerosol and subcutaneous routes, was assessed in 562 healthy children. Rates of rubella seroconversion and geometric mean titers (GMT) were similar for both routes. Rates of measles PN seroconversion, GMT and measles ELISA post-vaccination seropositivity and seroconversion rate were each higher f...
متن کاملAerosolized measles and measles-rubella vaccines induce better measles antibody booster responses than injected vaccines: randomized trials in Mexican schoolchildren.
OBJECTIVE To compare antibody responses and side-effects of aerosolized and injected measles vaccines after revaccination of children enrolling in elementary schools. METHODS Vaccines for measles (Edmonston-Zagreb) or measles-rubella (Edmonston-Zagreb with RA27/3) were given by aerosol or injection to four groups of children. An additional group received Schwarz measles vaccine by injection. ...
متن کاملMass Measles Vaccination Campaign in Aila Cyclone-Affected Areas of West Bengal, India: An In-depth Analysis and Experiences
Disaster-affected populations are highly vulnerable to outbreaks of measles. Therefore, a mass vaccination against measles was conducted in Aila cyclone-affected blocks of West Bengal, India in July 2009. The objectives of the present report were to conduct an in depth analysis of the campaign, and to discuss the major challenges. A block level micro-plan, which included mapping of the villages...
متن کاملRelevant Facts from Aerosol Measles Vaccine Studies
Most of the facts regarding measles aerosol vaccination have been quite thoroughly dealt with in the book by S. Plotkin, Mass Vaccination: Global Aspects—Progress and Obstacles (2006 Ed) [1]. However, there are some aspects mentioned there that should perhaps have been emphasized more strongly and others that have emerged as relevant issues since then. We shall start with the quite important po...
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